| Gene Symbol | MAP2K4 |
|---|---|
| Entrez Gene | 6416 |
| Alt Symbol | JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1, SKK1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | mitogen-activated protein kinase kinase 4 |
| Other Description | JNK-activated kinase 1|JNK-activating kinase 1|MAP kinase kinase 4|MAPK/ERK kinase 4|MAPKK 4|MEK 4|SAPK/ERK kinase 1|c-Jun N-terminal kinase kinase 1|dual specificity mitogen-activated protein kinase kinase 4|stress-activated protein kinase kinase 1 |
| Swissprots | Q6FHX4 Q5U0B8 P45985 B2R7N7 Q6PIE6 D3DTS5 Q6P9H2 B3KYB2 |
| Accessions | AAC24130 AAY22176 EAW89973 EAW89974 EAW89975 EAW89976 P45985 AA293365 AK122997 AK131544 BAG54774 AK294923 BAG58005 AK313053 BAG35884 AK316100 BAH14471 AK316177 BAH14548 AU150695 BC036032 AAH36032 BC050386 BC060764 AAH60764 BQ028457 BT019676 AAV38482 CR536564 CAG38801 L31902 L36870 AAC41719 U17743 AAC50127 XM_005256753 XP_005256810 XM_005256755 XP_005256812 XM_011523976 XP_011522278 XM_011523977 XP_011522279 XR_934080 NM_001281435 NP_001268364 NM_003010 NP_003001 |
| Function | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/J |
| Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. |
| Tissue Specificity | Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues. |
| Top Pathways | TNF signaling pathway, Toll-like receptor signaling pathway, Epstein-Barr virus infection, Influenza A, HTLV-I infection |