| Gene Symbol | Cyp8b1 |
|---|---|
| Entrez Gene | 13124 |
| Alt Symbol | - |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | cytochrome P450, family 8, subfamily b, polypeptide 1 |
| Other Description | 7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase|7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase|CYPVIIIB1|cytochrome P450 8B1|cytochrome P450, 8b1, sterol 12 alpha-hydrolase|sterol 12-alpha-hydrolase|sterol 12-alpha-hydroxylase |
| Swissprots | Q9R217 O88962 |
| Accessions | AAD19876 EDL09122 O88962 AF090317 AAC63036 BC010973 AAH10973 BC010974 AAH10974 BC049969 AAH49969 NM_010012 NP_034142 |
| Function | Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha- hydroxylated C27 steroids. |
| Subcellular Location | Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein. |
| Tissue Specificity | Expressed in liver. |
| Top Pathways | Primary bile acid biosynthesis, PPAR signaling pathway |