| Gene Symbol | CCL5 |
|---|---|
| Entrez Gene | 6352 |
| Alt Symbol | D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP |
| Species | Human |
| Gene Type | protein-coding |
| Description | chemokine (C-C motif) ligand 5 |
| Other Description | C-C motif chemokine 5|T-cell specific protein p288|beta-chemokine RANTES|eosinophil chemotactic cytokine|regulated upon activation, normally T-expressed, and presumably secreted|small inducible cytokine subfamily A (Cys-Cys), member 5 |
| Swissprots | Q4ZGJ1 Q9UBG2 O43646 Q9UC99 P13501 Q9NYA2 Q0QVW8 |
| Accessions | AAC63331 AAD14942 AAY22177 ACW84342 BAA76937 BAA76938 BAA76939 CAY55955 EAW80120 P13501 AA443491 AA486131 AF043341 AAC03541 AF266753 AAF73070 AK312212 BAG35145 AW769950 BC008600 AAH08600 BG272739 CB111656 CD695497 CR980938 DQ230537 ABB69929 DQ891490 ABM82416 DQ894681 ABM85607 GD136908 HY265548 M21121 AAA36725 NM_001278736 NP_001265665 NM_002985 NP_002976 |
| Function | Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1- infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1- 68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed:16791620, PubMed:1380064, PubMed:8525373, PubMed:9516414, PubMed:15923218). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobiliz |
| Subcellular Location | Secreted. |
| Tissue Specificity | T-cell and macrophage specific. |
| Top Pathways | TNF signaling pathway, Cytokine-cytokine receptor interaction, Herpes simplex infection, Influenza A, Rheumatoid arthritis |