Gene Symbol | ITSN2 |
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Entrez Gene | 50618 |
Alt Symbol | PRO2015, SH3D1B, SH3P18, SWA, SWAP |
Species | Human |
Gene Type | protein-coding |
Description | intersectin 2 |
Other Description | SH3 domain-containing protein 1B|SH3P18-like WASP-associated protein|intersectin-2 |
Swissprots | Q9HAK4 O95062 Q9NZM3 Q9NYG0 Q9NXE6 Q9NZM2 Q15812 Q9ULG4 |
Accessions | AAX93122 AAX93123 AAY14668 EAX00750 EAX00751 EAX00752 EAX00753 Q9NZM3 AB033082 BAA86570 AF001630 AAD00899 AF038189 AF182198 AAF59903 AF182199 AAF59904 AF248540 AAF63600 AK000302 BAA91068 AK021545 BAB13841 AK025400 AK091859 BC020921 AAH20921 BC038963 AAH38963 BC146779 AAI46780 DA382952 U61167 AAC50593 NM_006277 NP_006268 NM_019595 NP_062541 NM_147152 NP_671494 |
Function | Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). {ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}. |
Subcellular Location | Cytoplasm. |
Tissue Specificity | Ubiquitous. Isoform 1 is primarily expressed in adult heart and liver. |
Intersectin-2 CRISPR/Cas9 KO Plasmid (h) - sc-402531 from Santa Cruz Biotechnology
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Intersectin-2 HDR Plasmid (h) - sc-402531-HDR from Santa Cruz Biotechnology
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Intersectin-2 Double Nickase Plasmid (h) - sc-402531-NIC from Santa Cruz Biotechnology
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Intersectin-2 Double Nickase Plasmid (h2) - sc-402531-NIC-2 from Santa Cruz Biotechnology
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Intersectin-2 CRISPR Activation Plasmid (h) - sc-402531-ACT from Santa Cruz Biotechnology
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Intersectin-2 CRISPR Activation Plasmid (h2) - sc-402531-ACT-2 from Santa Cruz Biotechnology
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Intersectin-2 Lentiviral Activation Particles (h) - sc-402531-LAC from Santa Cruz Biotechnology
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Intersectin-2 Lentiviral Activation Particles (h2) - sc-402531-LAC-2 from Santa Cruz Biotechnology
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Intersectin-2 siRNA (h) - sc-41367 from Santa Cruz Biotechnology
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Intersectin-2 shRNA Plasmid (h) - sc-41367-SH from Santa Cruz Biotechnology
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Intersectin-2 shRNA (h) Lentiviral Particles - sc-41367-V from Santa Cruz Biotechnology
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Intersectin 2 RNAi - H00050618-R02 from Novus Biologicals
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Intersectin 2 RNAi - H00050618-R03 from Novus Biologicals
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MISSION® esiRNA - EHU064971 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10844 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10844 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12347 from Sigma-Aldrich
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ITSN2 siRNA (Human) - CRH9390 from Cohesion Biosciences
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Intersectin 2 RNAi - H00050618-R01 from Novus Biologicals
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ITSN2, siRNA - MBS8239441 from MyBioSource
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shRNA set against Human ITSN2 (NM_006277.2) - SHH321753 from Creative biogene
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Human ITSN2 siRNA - orb269892 from Biorbyt
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ITSN2 shRNA Plasmid (Human) - CHH9390 from Cohesion Biosciences
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ITSN2 miRNA 3'UTR clone - MiUTR3H-06823 from Creative biogene
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ITSN2 miRNA 3'UTR clone - MiUTR3H-06824 from Creative biogene
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