| Gene Symbol | SRC |
|---|---|
| Entrez Gene | 6714 |
| Alt Symbol | ASV, SRC1, c-SRC, p60-Src |
| Species | Human |
| Gene Type | protein-coding |
| Description | SRC proto-oncogene, non-receptor tyrosine kinase |
| Other Description | proto-oncogene c-Src|proto-oncogene tyrosine-protein kinase Src|protooncogene SRC, Rous sarcoma|tyrosine kinase pp60c-src|tyrosine-protein kinase SRC-1|v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog |
| Swissprots | Q76P87 E1P5V4 P12931 Q9H5A8 Q86VB9 |
| Accessions | AAA60584 AAB59543 AAC29427 CAA26485 CAN37623 EAW76062 EAW76063 EAW76064 EAW76065 EAW76066 EAW76067 P12931 AF272982 AK024281 BAB14871 AK091756 AW135290 BC011566 AAH11566 BC051270 AAH51270 CD364525 EU831426 ACE87113 EU831519 ACE86438 HY016645 JF432365 ADZ15582 Z18364 XM_011529013 XP_011527315 XM_011529014 XP_011527316 NM_005417 NP_005408 NM_198291 NP_938033 |
| Function | Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein- coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasm |
| Subcellular Location | Cell membrane. Mitochondrion inner membrane. Nucleus. Cytoplasm, cytoskeleton. Note=Localizes to focal adhesion sites following integrin engagement. Localization to focal adhesion sites requires myristoylation and the SH3 domain. |
| Tissue Specificity | Expressed ubiquitously. Platelets, neurons and osteoclasts express 5-fold to 200-fold higher levels than most other tissues. |
| Top Pathways | Inflammatory mediator regulation of TRP channels, Proteoglycans in cancer, Rap1 signaling pathway, Estrogen signaling pathway, Oxytocin signaling pathway |