| Gene Symbol | trpl |
|---|---|
| Entrez Gene | 36003 |
| Alt Symbol | CG1694, CG18345, DmTRPL, Dmel\CG18345, TRP-Like, TRPL, TrpL, Trpl, dTRPL, dTrpL, trp-l |
| Species | Drosophila |
| Gene Type | protein-coding |
| Description | transient receptor potential-like |
| Other Description | CG18345-PA|CG18345-PB|CG18345-PD|TRP-like|transient receptor Potential-Like|trpl-PA|trpl-PB|trpl-PD |
| Swissprots | Q0E9E3 P48994 Q8IH62 Q8MKU9 Q9V5B2 C6TPC1 |
| Accessions | AAF58904 AAM68793 AAM68794 P48994 BT099607 ACU45760 NM_057547 NP_476895 NM_165694 NP_724822 NM_165695 NP_724823 |
| Function | A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction. Required for vision in the dark and in dim light. Binds calmodulin. Trp and trpl act together in the light response, although it is unclear whether as heteromultimers or distinct units. Also forms a functional cation channel with Trpgamma. Activated by fatty acids, metabolic stress, inositols and GTP-binding proteins. {ECO:0000269|PubMed:10908615, ECO:0000269|PubMed:11931743, ECO:0000269|PubMed:8918461, ECO:0000269|PubMed:9494079, ECO:0000269|PubMed:9930700}. |
| Subcellular Location | Membrane {ECO:0000269|PubMed:11931743, ECO:0000269|PubMed:9494079}; Multi-pass membrane protein {ECO:0000269|PubMed:11931743, ECO:0000269|PubMed:9494079}. Note=In the dark, there is 20 fold more rhabdomeral trpl protein forming plasma membrane channels than in the light. In the light, the protein translocates to an intracellular compartment. Protein levels remain unchanged in light and dark conditions. |
| Tissue Specificity | Expressed predominantly in the rhabdomeres of photoreceptor cells. {ECO:0000269|PubMed:1314616}. |
| Top Pathways | Phototransduction - fly |