| Gene Symbol | mats |
|---|---|
| Entrez Gene | 42634 |
| Alt Symbol | CG13852, DMob1, Dmel\CG13852, Dmob1, Mats, Mob1, anon-WO0118547.303, dmob1 |
| Species | Drosophila |
| Gene Type | protein-coding |
| Description | mob as tumor suppressor |
| Other Description | CG13852-PA|CG13852-PB|CG13852-PC|Mob as tumor suppressor|mats-PA|mats-PB|mats-PC |
| Swissprots | Q9VD10 Q95RA8 |
| Accessions | AAF55993 AGB96215 AHN57464 Q95RA8 AY061520 AAL29068 NM_001275906 NP_001262835 NM_001300536 NP_001287465 NM_142784 NP_651041 |
| Function | Coactivator of Warts (Wts) kinase in the Hippo/SWH (Sav/Wts/Hpo)signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki)oncoprotein. The Hippo/SWH signaling pathway inhibits the activity of the transcriptional complex formed by Scalloped (sd) and Yki and the target genes of this pathway include cyclin-E (cycE), diap1 and bantam. Mats is essential for early development and is required for proper chromosomal segregation in developing embryos. {ECO:0000269|PubMed:15766530, ECO:0000269|PubMed:15975907, ECO:0000269|PubMed:17347649, ECO:0000269|PubMed:18245354, ECO:0000269|PubMed:19913529}. |
| Subcellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cytoplasm, cytosol. Cell membrane. Note=Colocalizes with wts and cyclin E at the centrosome. |
| Tissue Specificity | Ubiquitously expressed at low levels in developing tissues (at protein level). {ECO:0000269|PubMed:18245354}. |
| Top Pathways | Hippo signaling pathway - fly |