| Gene Symbol | DAO |
|---|---|
| Entrez Gene | 1610 |
| Alt Symbol | DAAO, DAMOX, OXDA |
| Species | Human |
| Gene Type | protein-coding |
| Description | D-amino-acid oxidase |
| Other Description | D-amino acid oxidase |
| Swissprots | B2R7I5 Q16758 P14920 Q8N6R2 |
| Accessions | BAA20974 EAW97834 EAW97835 EAW97836 EAW97837 EAW97838 P14920 AK312995 BAG35832 AX741655 CAD90933 AX741656 CAD90934 AX741658 CAD90936 AX741659 CAD90937 AX776478 CAE11742 AX776479 CAE11743 AX776480 CAE11744 AX786386 CAE11959 BC029057 AAH29057 BC074770 AAH74770 BM932083 BX538210 CAD98069 DA085245 DQ890839 ABM81765 DQ893995 ABM84921 XM_005268692 XP_005268749 XM_011538004 XP_011536306 XM_011538005 XP_011536307 NM_001917 NP_001908 |
| Function | Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D- amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids. {ECO:0000269|PubMed:17303072}. |
| Subcellular Location | Peroxisome. |
| Top Pathways | Glycine, serine and threonine metabolism, Peroxisome, Arginine and proline metabolism, D-Arginine and D-ornithine metabolism |