| Gene Symbol | FGF2 |
|---|---|
| Entrez Gene | 2247 |
| Alt Symbol | BFGF, FGF-2, FGFB, HBGF-2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | fibroblast growth factor 2 (basic) |
| Other Description | basic fibroblast growth factor bFGF|fibroblast growth factor 2|heparin-binding growth factor 2|prostatropin |
| Swissprots | Q9UCS6 Q9UCS5 P09038 O00527 P78443 Q16443 Q7KZ11 Q7KZ72 A4LBB8 Q5PY50 Q9UC54 |
| Accessions | AAB21432 ABO43041 ADL14514 CAA28027 CAA28028 CAA28029 CAA73868 EAX05222 P09038 AA256481 AB451321 BAG70135 AB451450 BAG70264 AY820133 AAV70487 BC111737 BC166646 AAI66646 BE439775 BP292299 BU501243 CN315083 J04513 AAA52531 M17599 AAA52534 M27968 AAA52448 S47380 AAD13853 NM_002006 NP_001997 |
| Function | Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. {ECO:0000269|PubMed:1721615, ECO:0000269|PubMed:8663044}. |
| Subcellular Location | Secreted. Nucleus. Note=Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane. Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57. |
| Tissue Specificity | Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non- cancerous liver tissue. {ECO:0000269|PubMed:1417798, ECO:0000269|PubMed:1721615}. |
| Top Pathways | Melanoma, MAPK signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Rap1 signaling pathway |