| Gene Symbol | RAD51C |
|---|---|
| Entrez Gene | 5889 |
| Alt Symbol | BROVCA3, FANCO, R51H3, RAD51L2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | RAD51 paralog C |
| Other Description | DNA repair protein RAD51 homolog 3|RAD51-like protein 2|yeast RAD51 homolog 3 |
| Swissprots | Q3B783 O43503 O43502 |
| Accessions | AAT38108 EAW94430 EAW94431 EAW94432 EAW94433 EAW94434 O43502 AA304618 AF029669 AAC39604 AF029670 AAC39605 AI424321 AI914449 AK129738 AK290487 BAF83176 AK303363 BAG64422 BC000667 BC064578 BC073161 BC093930 AAH93930 BC101485 AAI01486 BC107753 AAI07754 BC143259 BM987503 BT007339 AAP36003 CB243543 XM_006722001 XP_006722064 XM_006722002 XP_006722065 XM_006722004 XP_006722067 XM_006722005 XP_006722068 XM_011525092 XP_011523394 XM_011525093 XP_011523395 XM_011525094 XP_011523396 XR_934513 XR_934514 NM_002876 NP_002867 NM_058216 NP_478123 NR_103872 NR_103873 |
| Function | Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Part of the RAD21 paralog protein complexes BCDX2 and CX3 which act at different stages of the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 seems to act downstream of BRCA2 recruitment and upstream of RAD51 recruitment; CX3 seems to act downstream of RAD51 recruitment; both complexes bind predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. Involved in RAD51 foci formation in response |
| Subcellular Location | Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Note=DNA damage induces an increase in nuclear levels. Accumulates in DNA damage induced nuclear foci or RAD51C foci which is formed during the S or G2 phase of cell cycle. Accumulation at DNA lesions requires the presence of NBN/NBS1, ATM and RPA. |
| Tissue Specificity | Expressed in a variety of tissues, with highest expression in testis, heart muscle, spleen and prostate. |
| Top Pathways | Homologous recombination, Fanconi anemia pathway |