| Gene Symbol | PXYLP1 |
|---|---|
| Entrez Gene | 92370 |
| Alt Symbol | ACPL2, HEL124, XYLP |
| Species | Human |
| Gene Type | protein-coding |
| Description | 2-phosphoxylose phosphatase 1 |
| Other Description | acid phosphatase-like 2|acid phosphatase-like protein 2|epididymis luminal protein 124|xylosyl phosphatase |
| Swissprots | Q8TE99 D3DNF5 W0TR04 Q49AJ2 |
| Accessions | EAW79007 EAW79008 EAW79009 Q8TE99 AB827640 BAO45795 AK074331 BAB85053 AK296292 BAH12305 AK297790 BAH12668 AK316121 BAH14492 AL137529 CAB70793 AY358460 AAQ88825 BC035834 AAH35834 BC036701 AAH36701 BX647621 CA421956 CD101677 CX762355 DC409719 EU794677 ACJ13731 XM_005247903 XP_005247960 XM_011513314 XP_011511616 XM_011513315 XP_011511617 XM_011513316 XP_011511618 NM_001037172 NP_001032249 NM_001282728 NP_001269657 NM_152282 NP_689495 |
| Function | Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1- 4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains. {ECO:0000269|PubMed:24425863}. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000269|PubMed:24425863}; Single-pass type II membrane protein {ECO:0000255}. Note=Colocalizes to Golgi apparatus in a B3GAT3-dependent manner. {ECO:0000269|PubMed:24425863}. |
| Tissue Specificity | Widely expressed. Strongly expressed in spleen, fetal liver, moderately in placenta, pancreas, kidney, thymus and colon. {ECO:0000269|PubMed:24425863}. |