| Gene Symbol | GSTP1 |
|---|---|
| Entrez Gene | 2950 |
| Alt Symbol | DFN7, FAEES3, GST3, GSTP, HEL-S-22, PI |
| Species | Human |
| Gene Type | protein-coding |
| Description | glutathione S-transferase pi 1 |
| Other Description | GST class-pi|GSTP1-1|deafness, X-linked 7|epididymis secretory protein Li 22|fatty acid ethyl ester synthase III|glutathione S-transferase P |
| Swissprots | P09211 Q5TZY3 Q15690 O00460 |
| Accessions | AAA56823 AAA64919 AAC13869 AAP72967 ACB45879 CAA30847 CAA30894 EAW74648 EAW74649 EAW74650 P09211 AY579414 BC010915 AAH10915 BC044846 BT019949 AAV38752 BT019950 AAV38753 CA946272 CR450361 CAG29357 D28456 BAA05822 DQ892738 ABM83664 DQ895985 ABM86911 EU794620 ACJ13674 GQ141553 ACT66687 GQ141554 ACT66688 M69113 U30897 AAC51280 U62589 AAC51237 X06547 CAA29794 X15480 CAA33508 NM_000852 NP_000843 |
| Function | Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration. {ECO:0000269|PubMed:21668448}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:19269317}. Mitochondrion {ECO:0000269|PubMed:19269317}. Nucleus {ECO:0000269|PubMed:19269317}. Note=The 83 N-terminal amino acids function as un uncleaved transit peptide, and arginine residues within it are crucial for mitochondrial localization. |
| Top Pathways | Prostate cancer, Chemical carcinogenesis, Glutathione metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450 |