PVRL3

Gene Symbol	PVRL3
Entrez Gene	25945
Alt Symbol	CD113, CDW113, NECTIN-3, PPR3, PRR3, PVRR3
Species	Human
Gene Type	protein-coding
Description	poliovirus receptor-related 3
Other Description	nectin 3|nectin-3|poliovirus receptor-related protein 3
Swissprots	Q9BVA9 Q8WVU4 Q6NVZ3 E9PFR0 Q9NQS3 Q8NC05 Q9Y412
Accessions	CAD35242 CCF77054 EAW79703 Q9NQS3 AA555086 AF282874 AAF97597 AK075105 BAC11404 AL050071 CAB43256 BC001336 AAH01336 BC017572 AAH17572 BC067808 AAH67808 BI464010 BQ025085 XM_005247322 XP_005247379 XM_011512662 XP_011510964 XM_011512663 XP_011510965 XM_011512664 XP_011510966 XM_011512665 XP_011510967 XM_011512666 XP_011510968 XM_011512667 XP_011510969 XR_924122 NM_001243286 NP_001230215 NM_001243288 NP_001230217 NM_015480 NP_056295
Function	Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body. {ECO:0000269|PubMed:16216929}.
Subcellular Location	Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}.
Tissue Specificity	Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines. {ECO:0000269|PubMed:11024295}.
Top Pathways	Adherens junction, Cell adhesion molecules (CAMs)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Nectin 3 full length protein - ab153257 from Abcam Category Protein Source Wheat germ Species Human

Human Nectin 3 protein fragment - ab153787 from Abcam Category Protein Source HEK 293 cells Species Human

Human Nectin 3 protein fragment - ab153258 from Abcam Category Protein Source Wheat germ Species Human

PVRL3 / Nectin-3 Antibody Blocking Peptide - LS-E2006 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PVRL3 / Nectin-3 Antibody Blocking Peptide - LS-E15625 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PVRL3 / Nectin-3 Antibody Blocking Peptide - LS-E15624 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Nectin-3/PVRL3 Protein - H00025945-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Nectin-3/PVRL3 Partial Recombinant Protein - H00025945-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Nectin-3/PVRL3 Recombinant Protein - H00025945-G01 from Novus Biologicals Category Protein Prices $579.00 Sizes 10 µg Species Human

PVRL3-Antibody-C-term-Blocking-peptide - BP12866b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Nectin-3, CF - 3064-N3-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Leu56-Asp400 & Gly58-Asp400, with a C-terminal 6-His tag

Human PVRL3 protein - orb49552 from Biorbyt Category Protein Prices $272.00, $366.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Human PVRL3 His tag protein - orb83363 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Species Human

Nectin 3 Blocking Peptide - 33R-10935 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

PVRL3 Blocking Peptide - 33R-8473 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PVRL3 Blocking Peptide - 33R-7025 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Human PVRL3 Protein - abx068624 from Abbexa Category Protein Source E.coli Species Human

CD113 / Nectin 3 - H00025945-G01 from Acris Antibodies Category Protein Prices $550.00 Sizes 10 µg Species Human

CD113 / Nectin 3 - H00025945-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

CD113 / Nectin 3 - H00025945-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

CD113 / Nectin 3 - H00025945-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CD113 / Nectin 3 - H00025945-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Nectin-3, Human, Recombinant - 19-C630 from ARP American Research Products Category Protein Prices $109.00 Sizes 10 µg Source HEK293 Species Human

PVRL3, Nectin 3 fusion protein - Ag1712 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human PVRL3 Protein - BP001188-C630 from Syd Labs Category Protein Prices $98.00, $264.00, $2,640.00 Sizes 10 µg, 50 µg, 1 mg Source HEK 293-derived. Species Human

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