| Gene Symbol |
APOBEC3A
|
| Entrez Gene |
200315
|
| Alt Symbol |
A3A, ARP3, PHRBN, bK150C2.1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
|
| Other Description |
DNA dC->dU-editing enzyme APOBEC-3A|phorbolin 1|phorbolin-1|probable DNA dC->dU-editing enzyme APOBEC-3A
|
| Swissprots |
Q5JZ93 A0AVM1 P31941 Q12807 Q9UH18
|
| Accessions |
EAW60278 P31941 BC126416 AAI26417 BC144146 AAI44147 BI029063 CR456393 CAG30279 CU012950 CAK54381 CU013238 CAK54680 DB322320 HQ258100 ADR82854 U03891 AAA03706 NM_001270406 NP_001257335 NM_145699 NP_663745
|
| Function |
DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno- associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. {ECO:0000269|PubMed:10469298, ECO:0000269|PubMed:12859895, ECO:0000269|PubMed:16527742, ECO:0000269|PubMed:19461882, ECO:0000269|PubMed:20062055, ECO:0000269|PubMed:20615867, ECO:0000269|PubMed:21123384, ECO:0000269|PubMed:21368204, ECO:0000269|PubMed:21460793, ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:22457529, ECO:0000269|PubMed:22896697}.
|
| Subcellular Location |
Nucleus. Cytoplasm.
|
| Tissue Specificity |
Expressed in peripheral leukocytes with higher expression in CD14-positive phagocytic cells. Highly expressed in keratinocytes and in periphery blood monocytes. Also detected in non-lymphoid tissues including lung and adipose tissues. Found at high levels in colorectal adenocarcinoma, Burkitt's lymphoma and chronic myelogenous leukemia. {ECO:0000269|PubMed:11863358, ECO:0000269|PubMed:16527742, ECO:0000269|PubMed:20062055, ECO:0000269|PubMed:20308164}.
|