| Gene Symbol | AKR1B1 |
|---|---|
| Entrez Gene | 231 |
| Alt Symbol | ADR, ALDR1, ALR2, AR |
| Species | Human |
| Gene Type | protein-coding |
| Description | aldo-keto reductase family 1, member B1 (aldose reductase) |
| Other Description | Lii5-2 CTCL tumor antigen|aldehyde reductase 1|aldo-keto reductase family 1 member B1|aldose reductase|low Km aldose reductase |
| Swissprots | Q6FGA4 P15121 Q9UCI9 Q9BS21 Q6ICP2 Q5U031 B2R8N3 |
| Accessions | AAA35561 AAA51712 AAB61992 AAB88851 CBX51392 EAL24070 EAW83814 EAW83815 P15121 AB209796 BAD93033 AF328729 AAN09721 AK311339 AK313439 BAG36230 AL833410 BC000260 AAH00260 BC005387 AAH05387 BC010391 AAH10391 BT019859 AAV38662 CR450351 CAG29347 CR542203 CAG47000 DQ890758 ABM81684 DQ892546 ABM83472 DQ893921 ABM84847 DQ895757 ABM86683 J04795 AAA51713 J05017 AAA51714 J05474 AAA51715 M34720 AAA35560 X15414 CAA33460 XM_005250234 XP_005250291 NM_001628 NP_001619 |
| Function | Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. |
| Subcellular Location | Cytoplasm. |
| Tissue Specificity | Highly expressed in embryonic epithelial cells (EUE) in response to osmotic stress. {ECO:0000269|PubMed:8435445}. |
| Top Pathways | Pentose and glucuronate interconversions, Glycerolipid metabolism, Galactose metabolism, Fructose and mannose metabolism |