| Gene Symbol | NOS1 |
|---|---|
| Entrez Gene | 4842 |
| Alt Symbol | IHPS1, N-NOS, NC-NOS, NOS, bNOS, nNOS |
| Species | Human |
| Gene Type | protein-coding |
| Description | nitric oxide synthase 1 (neuronal) |
| Other Description | NOS type I|constitutive NOS|neuronal NOS|nitric oxide synthase, brain|peptidyl-cysteine S-nitrosylase NOS1 |
| Swissprots | O75713 E9PH30 P29475 |
| Accessions | AAB60654 AAR07069 CCQ42990 EAW98108 EAW98109 EAW98110 P29475 AF446131 AF446132 AF446133 AF446134 AF446135 AF446136 AF446137 AF446138 AF446139 AF446140 AJ004918 CAA06218 AK294435 BAG57679 AK307481 BC010126 BC033208 AAH33208 BC156399 AAI56400 BC172474 AAI72474 BE207961 D16408 BAA03895 EU753241 ACF04132 L02881 AAA36376 U17327 AAA62405 U31466 AAB49040 XM_011538398 XP_011536700 NM_000620 NP_000611 NM_001204213 NP_001191142 NM_001204214 NP_001191143 NM_001204218 NP_001191147 |
| Function | Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. |
| Subcellular Location | Cell membrane, sarcolemma; Peripheral membrane protein. Cell projection, dendritic spine {ECO:0000250}. Note=In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons, enriched in dendritic spines (By similarity). {ECO:0000250}. |
| Tissue Specificity | Isoform 1 is ubiquitously expressed: detected in skeletal muscle and brain, also in testis, lung and kidney, and at low levels in heart, adrenal gland and retina. Not detected in the platelets. Isoform 3 is expressed only in testis. Isoform 4 is detected in testis, skeletal muscle, lung, and kidney, at low levels in the brain, but not in the heart and adrenal gland. |
| Top Pathways | Circadian entrainment, Phagosome, Salivary secretion, Calcium signaling pathway, Amyotrophic lateral sclerosis (ALS) |