| Gene Symbol | kibra |
|---|---|
| Entrez Gene | 41783 |
| Alt Symbol | CG12600, CG33967, CG7552, Dmel\CG33967, Kib, Kibra, ORE-2, RE26350, kib, l(3)02404, l(3)j5C3, l(3)neo42 |
| Species | Drosophila |
| Gene Type | protein-coding |
| Description | kibra ortholog |
| Other Description | CG33967-PA|CG33967-PB|kibra-PA|kibra-PB|lethal (3) neo42 |
| Swissprots | Q5BIC8 Q9VFG8 |
| Accessions | AAF55090 AHN57328 Q9VFG8 NM_001038966 NP_001034055 NM_001300400 NP_001287329 |
| Function | Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Kibra acts synergistically along with Ex and Mer to regulate the Hippo signaling pathway. {ECO:0000269|PubMed:20159598, ECO:0000269|PubMed:20159599, ECO:0000269|PubMed:20159600}. |
| Subcellular Location | Cytoplasm. Apical cell membrane. Note=Localizes at the apical cortex of epithelial cells and cytoplasmic, punctate. |
| Tissue Specificity | Expressed in ovarian posterior follicle cells and wing disks (at protein level). {ECO:0000269|PubMed:20159599}. |
| Top Pathways | Hippo signaling pathway - fly |