| Gene Symbol | CDH5 |
|---|---|
| Entrez Gene | 1003 |
| Alt Symbol | 7B4, CD144 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cadherin 5, type 2 (vascular endothelium) |
| Other Description | 7B4 antigen|VE-cadherin|cadherin 5, type 2, VE-cadherin (vascular epithelium)|cadherin-5|cd144 antigen|endothelial-specific cadherin|vascular endothelial cadherin |
| Swissprots | Q4VAI6 Q4VAI5 P33151 |
| Accessions | EAW83009 P33151 AB035304 BAA87418 AB209908 BAD93145 AK300299 BAG62052 AK300322 BAG62074 AK300461 BAG62180 BC096363 AAH96363 BC096364 AAH96364 BC096365 AAH96365 BC117520 AAI17521 DC381809 U84722 AAB41796 X59796 CAA42468 X79981 CAA56306 XM_011522801 XP_011521103 NM_001795 NP_001786 NM_001114117 |
| Function | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction. {ECO:0000269|PubMed:20332120, ECO:0000269|PubMed:21269602}. |
| Subcellular Location | Cell junction {ECO:0000269|PubMed:20332120}. Cell membrane {ECO:0000305|PubMed:20332120}; Single-pass type I membrane protein {ECO:0000305|PubMed:20332120}. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions. |
| Tissue Specificity | Endothelial tissues and brain. |
| Top Pathways | Leukocyte transendothelial migration, Cell adhesion molecules (CAMs) |