| Gene Symbol | ABL2 |
|---|---|
| Entrez Gene | 27 |
| Alt Symbol | ABLL, ARG |
| Species | Human |
| Gene Type | protein-coding |
| Description | ABL proto-oncogene 2, non-receptor tyrosine kinase |
| Other Description | Abelson tyrosine-protein kinase 2|abelson-related gene protein|c-abl oncogene 2, non-receptor tyrosine kinase|tyrosine-protein kinase ARG|v-abl Abelson murine leukemia viral oncogene homolog 2 |
| Swissprots | B7UEF4 Q5T0X6 A0M8X0 Q5W0C5 P42684 B7UEF5 Q6NZY6 Q7Z301 B7UEF3 B7UEF2 |
| Accessions | AAY16984 EAW91040 EAW91041 P42684 AK025877 AK056280 AK225255 AK309549 AK311045 BC065912 AAH65912 BQ014912 BX538317 CAD98092 DA596675 DB280398 FJ542283 ACK76601 FJ542284 ACK76602 FJ542285 ACK76603 FJ542286 ACK76604 M35296 AAA35553 XM_005245088 XP_005245145 XR_921764 XR_921765 NM_001136000 NP_001129472 NM_001136001 NP_001129473 NM_001168236 NP_001161708 NM_001168237 NP_001161709 NM_001168238 NP_001161710 NM_001168239 NP_001161711 NM_005158 NP_005149 NM_007314 NP_009298 |
| Function | Non-receptor tyrosine-protein kinase that plays an ABL1- overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin- bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endo |
| Subcellular Location | Cytoplasm, cytoskeleton. |
| Tissue Specificity | Widely expressed. |
| Top Pathways | ErbB signaling pathway |