| Gene Symbol | PLA2G16 |
|---|---|
| Entrez Gene | 11145 |
| Alt Symbol | AdPLA, H-REV107-1, HRASLS3, HREV107, HREV107-1, HREV107-3, HRSL3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | phospholipase A2, group XVI |
| Other Description | Ca-independent phospholipase A1/2|H-rev 107 protein homolog|HRAS-like suppressor 1|HRAS-like suppressor 3|adipose-specific PLA2|adipose-specific phospholipase A2|group XVI phospholipase A1/A2|group XVI phospholipase A2|renal carcinoma antigen NY-REN-65 |
| Swissprots | Q3SYI3 B7XAK5 B2R7Q4 P53816 Q9HDD1 |
| Accessions | EAW74158 EAW74159 EAW74160 P53816 AB030814 BAB08108 AB439591 BAH08749 AF317086 AAL26892 AI374456 AI590735 AK313075 BAG35901 AU099540 AX775893 CAE11646 BC001387 AAH01387 BC103807 AAI03808 BC103808 AAI03809 BG719903 CK003948 DQ892568 ABM83494 DQ895783 ABM86709 X92814 CAA63423 XM_006718426 XP_006718489 XM_011544741 XP_011543043 NM_001128203 NP_001121675 NM_007069 NP_009000 |
| Function | Exhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Specifically catalyzes the release of fatty acids from phospholipids in adipose tissue (By similarity). N- and O- acylation activity is hardly detectable. Might decrease protein phosphatase 2A (PP2A) activity. {ECO:0000250, ECO:0000269|PubMed:17374643, ECO:0000269|PubMed:19615464}. |
| Subcellular Location | Cytoplasm. Cytoplasm, perinuclear region {ECO:0000250}. Membrane; Single-pass membrane protein. |
| Tissue Specificity | Widely expressed. low expression, if any, in hematopoietic cells and thymus. In testis, confined to round spermatids. Expressed in normal ovarian epithelial cells. Down- regulated in some ovarian carcinomas and testicular germ cell tumors. {ECO:0000269|PubMed:11526504, ECO:0000269|PubMed:11973642, ECO:0000269|PubMed:19615464, ECO:0000269|PubMed:9771974}. |
| Top Pathways | Ether lipid metabolism, Arachidonic acid metabolism, Linoleic acid metabolism, alpha-Linolenic acid metabolism, Glycerophospholipid metabolism |