Gene Symbol | SH3GLB1 |
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Entrez Gene | 51100 |
Alt Symbol | Bif-1, CGI-61, PPP1R70, dJ612B15.2 |
Species | Human |
Gene Type | protein-coding |
Description | SH3-domain GRB2-like endophilin B1 |
Other Description | Bax-interacting factor 1|SH3 domain-containing GRB2-like protein B1|SH3-containing protein SH3GLB1|endophilin-B1|protein phosphatase 1, regulatory subunit 70 |
Swissprots | Q9H3Z0 Q5H8U5 Q9NR47 Q9Y371 Q9NYA9 B4E182 |
Accessions | EAW73181 EAW73182 Q9Y371 AB007960 BAD88797 AF151819 AAD34056 AF257318 AAF81225 AF263293 AAF73017 AF350371 AAK27365 AI936794 AK001954 BAA91999 AK225864 AK303710 BAG64694 BC007455 AAH07455 DB038227 DB451777 DQ893029 ABM83955 DQ896273 ABM87272 XM_006710672 XP_006710735 XM_006710673 XP_006710736 XM_011541538 XP_011539840 NM_001206651 NP_001193580 NM_001206652 NP_001193581 NM_001206653 NP_001193582 NM_016009 NP_057093 |
Function | May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion. {ECO:0000269|PubMed:11161816, ECO:0000269|PubMed:11604418, ECO:0000269|PubMed:15452144}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:15452144}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Mitochondrion outer membrane {ECO:0000269|PubMed:15452144}; Peripheral membrane protein {ECO:0000269|PubMed:15452144}. Note=Association with the Golgi apparatus depends on the cell type. {ECO:0000250}. |
Tissue Specificity | Highly expressed in heart, skeletal muscle, kidney and placenta. Detected at lower levels in brain, colon, thymus, spleen, liver, small intestine, lung and peripheral blood leukocytes. {ECO:0000269|PubMed:11161816, ECO:0000269|PubMed:11259440}. |
Top Pathways | Endocytosis |
Bif-1 Antibody - 4467 from Cell Signaling Technology
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Endophilin B1 (G-6) - sc-374146 from Santa Cruz Biotechnology
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Endophilin B1 (A-9) - sc-393191 from Santa Cruz Biotechnology
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Endophilin B1 (M-62) - sc-134843 from Santa Cruz Biotechnology
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Endophilin B1 (P-14) - sc-50565 from Santa Cruz Biotechnology
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Endophilin B1 (S-20) - sc-50566 from Santa Cruz Biotechnology
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Endophilin B1 (30A882) - sc-52924 from Santa Cruz Biotechnology
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Endophilin B1/2 (N-19) - sc-50568 from Santa Cruz Biotechnology
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Anti-Bif antibody - ab52981 from Abcam
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Anti-Bif antibody - ab117108 from Abcam
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Anti-Bif antibody - ab76043 from Abcam
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Anti-Bif antibody - ab1343 from Abcam
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Anti-Bif antibody [1B3-A5] - ab110091 from Abcam
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Anti-Bif antibody [EPR11857] - ab180135 from Abcam
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Anti-Bif antibody - C-terminal - ab154236 from Abcam
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Anti-SH3GLB1 / Bif / Endophilin B1 Antibody (N-Terminus) - LS-C125181 from LifeSpan Bioscience
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Anti-SH3GLB1 / Bif / Endophilin B1 Antibody (phospho-Tyr80, APC) - LS-C234958 from LifeSpan Bioscience
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Anti-SH3GLB1 / Bif / Endophilin B1 Antibody (phospho-Tyr80, AP) - LS-C234959 from LifeSpan Bioscience
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Anti-SH3GLB1 / Bif / Endophilin B1 Antibody (phospho-Tyr80, Biotin) - LS-C234960 from LifeSpan Bioscience
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Anti-SH3GLB1 / Bif / Endophilin B1 Antibody (phospho-Tyr80, FITC) - LS-C234961 from LifeSpan Bioscience
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Anti-SH3GLB1 / Bif / Endophilin B1 Antibody (phospho-Tyr80, PE) - LS-C234966 from LifeSpan Bioscience
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Anti-SH3GLB1 / Bif / Endophilin B1 Antibody (Tyr80, AP) - LS-C245817 from LifeSpan Bioscience
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Anti-SH3GLB1 / Bif / Endophilin B1 Antibody (aa58-107) - LS-C145243 from LifeSpan Bioscience
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Anti-SH3GLB1 / Bif / Endophilin B1 Antibody (Tyr80, APC) - LS-C245818 from LifeSpan Bioscience
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Anti-SH3GLB1 / Bif / Endophilin B1 Antibody (Tyr80, Biotin) - LS-C245819 from LifeSpan Bioscience
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