| Gene Symbol | MAP3K14 |
|---|---|
| Entrez Gene | 9020 |
| Alt Symbol | FTDCR1B, HS, HSNIK, NIK |
| Species | Human |
| Gene Type | protein-coding |
| Description | mitogen-activated protein kinase kinase kinase 14 |
| Other Description | NF-kappa-beta-inducing kinase|serine/threonine-protein kinase NIK |
| Swissprots | D3DX67 A8K2D8 Q8IYN1 Q99558 |
| Accessions | ABC40733 EAW51529 EAW51530 Q99558 AA564389 AJ008135 AJ008136 AJ008137 AJ008138 AJ008139 AJ008140 AJ008141 AJ008142 AJ008143 AJ008144 AJ008145 AJ008146 AJ008147 AJ008148 AJ008149 AJ008150 AJ008151 AJ008152 AJ008153 AJ008156 AJ008157 AJ008158 AJ008159 AJ008160 AJ008161 AJ008162 AJ008163 AK123696 AK131438 BAD18584 AK290203 BAF82892 AK313085 BC022296 BC035576 AAH35576 BE645094 BU623799 CR749592 CAH18391 DA856801 DQ894064 ABM84990 HY096069 HY287427 Y10256 CAA71306 XM_011525441 XP_011523743 XR_934591 XR_951536 XR_952490 NM_003954 NP_003945 |
| Function | Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non- canonical pathway. Could act in a receptor-selective manner. {ECO:0000269|PubMed:15084608}. |
| Subcellular Location | Cytoplasm. |
| Tissue Specificity | Weakly expressed in testis, small intestine, spleen, thymus, peripheral blood leukocytes, prostate, ovary and colon. {ECO:0000269|PubMed:9020361}. |
| Top Pathways | TNF signaling pathway, Apoptosis, Epstein-Barr virus infection, HTLV-I infection, Osteoclast differentiation |