| Gene Symbol | GCK |
|---|---|
| Entrez Gene | 2645 |
| Alt Symbol | FGQTL3, GK, GLK, HHF3, HK4, HKIV, HXKP, LGLK, MODY2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | glucokinase (hexokinase 4) |
| Other Description | ATP:D-hexose 6-phosphotransferase|HK IV|glucokinase|hexokinase D, pancreatic isozyme|hexokinase type IV|hexokinase-4|hexokinase-D |
| Swissprots | A4D2J2 A4D2J3 Q05810 P35557 |
| Accessions | AAA67541 AAA67542 AAB97680 AAB97681 AAB97682 AGA96145 AGH08211 AGH08212 AGH08213 AGH08214 AGH08215 AGH08216 AGH08217 AGH08218 AGH08220 AGH08221 AGH08222 AGH08223 CBF63115 CBU87991 EAL23764 EAL23765 EAL23766 EAW61114 EAW61115 EAW61116 P35557 AK122876 BAG53774 BC001890 AAH01890 BT007062 AAP35711 CD251038 DA640823 DQ893835 ABM84761 EU008605 ABS31137 M69051 AAB59563 M88011 AAA51824 M90299 AAA52562 NM_000162 NP_000153 NM_033507 NP_277042 NM_033508 NP_277043 |
| Function | Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:10456334}. Nucleus {ECO:0000269|PubMed:10456334}. Note=Under low glucose concentrations, GCK associates with GKRP and the inactive complex is recruited to the hepatocyte nucleus. |
| Tissue Specificity | Isoform 1 is expressed in pancreas. Isoform 2 and isoform 3 is expressed in liver. |
| Top Pathways | Glucagon signaling pathway, Central carbon metabolism in cancer, Insulin signaling pathway, Prolactin signaling pathway, Glycolysis / Gluconeogenesis |