| Gene Symbol | BTK |
|---|---|
| Entrez Gene | 695 |
| Alt Symbol | AGMX1, AT, ATK, BPK, IMD1, PSCTK1, XLA |
| Species | Human |
| Gene Type | protein-coding |
| Description | Bruton agammaglobulinemia tyrosine kinase |
| Other Description | B-cell progenitor kinase|agammaglobulinaemia tyrosine kinase|dominant-negative kinase-deficient Brutons tyrosine kinase|truncated Bruton agammaglobulinemia tyrosine kinase|tyrosine-protein kinase BTK|tyrosine-protein kinase BTK isoform (lacking exon 14) |
| Swissprots | B2RAW1 Q32ML5 Q06187 |
| Accessions | AAA61479 AAB60639 AAB64205 AAC51347 AAZ38824 EAX02856 EAX02857 EAX02858 Q06187 AF153364 AAF61477 AF153755 AAF37332 AF153756 AAF37333 AF153757 AAF37334 AF153758 AAF37335 AF153759 AAF37336 AF153760 AAF37337 AF153761 AAF37338 AF153762 AAF37339 AF153763 AAF37340 AF153764 AAF37341 AJ888376 CAI59842 AJ888377 CAI59836 AJ888378 CAI59837 AJ888379 CAI59838 AJ888380 CAI59839 AJ888381 CAI59840 AK057105 BAG51864 AK225577 AK309851 AK314382 BAG37008 AM051275 CAJ19681 AM051276 CAJ19682 AM051277 CAJ19683 AM051278 CAJ19684 AM051279 CAJ19685 AM051280 CAJ19686 AM051281 CAJ19687 AM051282 CAJ19688 AM051283 CAJ19689 AM051284 CAJ19690 AM051285 CAJ19691 AM051286 CAJ19692 AU107296 AV733045 BC109079 AAI09080 BC109080 AAI09081 DA619542 DB331677 DB636737 KF241986 AGW32074 X58957 CAA41728 NM_000061 NP_000052 NM_001287344 NP_001274273 NM_001287345 NP_001274274 |
| Function | Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK. BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways. Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway. The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense. E |
| Subcellular Location | Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. Note=In steady state, BTK is predominantly cytosolic. Following B-cell receptor (BCR) engagement by antigen, translocates to the plasma membrane through its PH domain. Plasma membrane localization is a critical step in the activation of BTK. A fraction of BTK also shuttles between the nucleus and the cytoplasm, and nuclear export is mediated by the nuclear export receptor CRM1. |
| Tissue Specificity | Predominantly expressed in B-lymphocytes. |
| Top Pathways | B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Primary immunodeficiency, Osteoclast differentiation |