| Gene Symbol | MAPK13 |
|---|---|
| Entrez Gene | 5603 |
| Alt Symbol | MAPK 13, MAPK-13, PRKM13, SAPK4, p38delta |
| Species | Human |
| Gene Type | protein-coding |
| Description | mitogen-activated protein kinase 13 |
| Other Description | MAP kinase 13|MAP kinase p38 delta|mitogen-activated protein kinase p38 delta|stress-activated protein kinase 4 |
| Swissprots | Q5U4A5 Q9UNU0 Q6FI46 O15264 O15124 O14739 |
| Accessions | EAX03874 EAX03875 EAX03876 O15264 AB209586 BAD92823 AB451221 BAG70035 AB451344 BAG70158 AF004709 AAC51374 AF015256 AAC51758 AF092535 AAD23377 AF100546 AAF36772 AK222922 BAD96642 AK308018 BC000433 AAH00433 BC001641 AAH01641 BC004428 AAH04428 BC085196 AAH85196 BM921729 BT007221 AAP35885 CR536490 CAG38729 CR541687 CAG46488 DB335275 DB473379 DQ588728 DQ891372 ABM82298 DQ894551 ABM85477 DR006449 EU832156 ACE87506 EU832250 ACE86820 U93232 AAB87639 Y10488 CAA71512 NM_002754 NP_002745 NR_072996 |
| Function | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an importan |
| Tissue Specificity | Expressed in testes, pancreas, small intestine, lung and kidney. Abundant in macrophages, also present in neutrophils, CD4+ T-cells, and endothelial cells. {ECO:0000269|PubMed:10201954, ECO:0000269|PubMed:9374491}. |
| Top Pathways | VEGF signaling pathway, Inflammatory mediator regulation of TRP channels, Sphingolipid signaling pathway, Retrograde endocannabinoid signaling, Proteoglycans in cancer |