| Gene Symbol |
CDC16
|
| Entrez Gene |
8881
|
| Alt Symbol |
ANAPC6, APC6, CUT9
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cell division cycle 16
|
| Other Description |
CDC16Hs|anaphase-promoting complex subunit 6|anaphase-promoting complex, subunit 6|cell division cycle 16 homolog|cell division cycle protein 16 homolog|cyclosome subunit 6
|
| Swissprots |
Q9Y564 Q13042 Q96AE6 Q7Z651 Q5T8C8 A2A365
|
| Accessions |
AAS94323 CCQ43240 EAX09237 EAX09238 EAX09239 EAX09240 EAX09241 EAX09242 EAX09243 EAX09244 EAX09245 Q13042 AB209850 BAD93087 AF164598 AAD45156 AK095082 AK296424 BAG59086 AK315302 BAG37707 AL540490 BC010875 AAH10875 BC017244 AAH17244 BC050575 U18291 AAC50200 XM_005266204 XP_005266261 XM_005266206 XP_005266263 XM_006719992 XP_006720055 XM_006719993 XP_006720056 XM_011534851 XP_011533153 XM_011534852 XP_011533154 XM_011534853 XP_011533155 XR_245358 XR_245359 XR_245360 XR_941424 NM_001078645 NP_001072113 NM_003903 NP_003894
|
| Function |
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:18485873}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:7736578}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:7736578}. Note=Colocalizes with CDC27 to the centrosome at all stages of the cell cycle and to the mitotic spindle.
|
| Top Pathways |
Cell cycle, Ubiquitin mediated proteolysis, Progesterone-mediated oocyte maturation, Oocyte meiosis, HTLV-I infection
|
![Western Blot: CDC16 Overexpression Lysate (Adult Normal) [NBL1-08990] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CDC16.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6559_CDC16%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-08990-img0002.jpg)