CDC16

Gene Symbol CDC16
Entrez Gene 8881
Alt Symbol ANAPC6, APC6, CUT9
Species Human
Gene Type protein-coding
Description cell division cycle 16
Other Description CDC16Hs|anaphase-promoting complex subunit 6|anaphase-promoting complex, subunit 6|cell division cycle 16 homolog|cell division cycle protein 16 homolog|cyclosome subunit 6
Swissprots Q9Y564 Q13042 Q96AE6 Q7Z651 Q5T8C8 A2A365
Accessions AAS94323 CCQ43240 EAX09237 EAX09238 EAX09239 EAX09240 EAX09241 EAX09242 EAX09243 EAX09244 EAX09245 Q13042 AB209850 BAD93087 AF164598 AAD45156 AK095082 AK296424 BAG59086 AK315302 BAG37707 AL540490 BC010875 AAH10875 BC017244 AAH17244 BC050575 U18291 AAC50200 XM_005266204 XP_005266261 XM_005266206 XP_005266263 XM_006719992 XP_006720055 XM_006719993 XP_006720056 XM_011534851 XP_011533153 XM_011534852 XP_011533154 XM_011534853 XP_011533155 XR_245358 XR_245359 XR_245360 XR_941424 NM_001078645 NP_001072113 NM_003903 NP_003894
Function Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:18485873}.
Subcellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:7736578}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:7736578}. Note=Colocalizes with CDC27 to the centrosome at all stages of the cell cycle and to the mitotic spindle.
Top Pathways Cell cycle, Ubiquitin mediated proteolysis, Progesterone-mediated oocyte maturation, Oocyte meiosis, HTLV-I infection

APC6 (D8D8) Rabbit mAb - 9499 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D8D8
Western blot analysis of extracts from 293T cells, either mock transfected (-) or transfected with a Myc/DDK-tagged cDNA expression construct encoding full-length human APC6 (hAPC6-Myc/DDK, +), using APC6 (D8D8) Rabbit mAb.

Cdc16 (E-4) - sc-365636 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cdc16 (E-4): sc-365636. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear and cytoplasmic localization.

Cdc16 (G-14) - sc-32508 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Cdc16 (F-4) - sc-365788 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cdc16 (F-4): sc-365788. Western blot analysis of Cdc16 expression in HeLa (A) and HuT 78 (B) whole cell lysates.

Cdc16 (H-300) - sc-5615 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Cdc16 (H-300): sc-5615. Western blot analysis of human recombinant Cdc16 fusion protein.

Cdc16 (D-1) - sc-376091 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cdc16 (D-1): sc-376091. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear and cytoplasmic localization.

Cdc16 (K-16) - sc-6395 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Cdc16 (K-16): sc-6395. Western blot analysis of Cdc16 expression in HeLa (A) and NIH/3T3 (B) whole cell lysates.

Cdc16 (N-18) - sc-6393 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Cdc16 (N-18): sc-6393. Western blot analysis of Cdc16 expression in HuT 78 (A), K-562 (B) and ALL-SIL (C) whole cell lysates.

Cdc16 (H-20) - sc-32510 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Apc6 (phospho S560) antibody - ab61075 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Apc6 (phospho S560) antibody (ab61075) at 1/500 dilutionLane 1 : extracts from HuvEc cellsLane 2 : extracts from HuvEc cells with phospho-peptide

Anti-Apc6 (phospho T580) antibody - ab12282 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Apc6 (phospho T580) antibody (ab12282) at 1/1000 dilutionLane 1 : Nocodazole treated HeLa whole cell lysateLane 2 : Asynchronous HeLa whole cell lysateLysates/proteins at 35 µg per lane.SecondaryGoat anti-Rabbit IgG at 1/10000 dilutionPerformed under reducing conditions.

Anti-Apc6 antibody - ab61189 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin embedded human breast carcinoma tissue using ab61189 at 1/50 dilution. Samples were treated -/+ peptide.

Anti-Apc6 antibody - ab106495 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of Apc6 in Human liver tissue with ab106495 at 20 ug/mL.

Anti-Apc6 antibody - ab72136 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Apc6 antibody (ab72136) at 0.04 µg/mlLane 1 : Whole cell lysate from Hela cells at 15 µgLane 2 : Whole cell lysate from Hela cells at 5 µgLane 3 : Whole cell lysate from Hela cells at 1.5 µgLane 4 : Whole cell lysate from Hela cells at 0.5 µgLane 5 : Whole cell lysate from NIH3T3 cells at 50 µg

Anti-Apc6 antibody - ab64876 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Apc6 antibody (ab64876) at 1/500 dilutionLane 1 : extracts from NIH-3T3 cells, (5-30 µg total protein).Lane 2 : extracts from NIH-3T3 cells, (5-30 µg total protein) with 5-10µg of the immunising peptide.

Anti-Apc6 antibody [EPR11167] - ab169537 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR11167
All lanes : Anti-Apc6 antibody [EPR11167] (ab169537) at 1/1000 dilutionLane 1 : HepG2 cell lysateLane 2 : HT1080 cell lysateLane 3 : HUVEC cell lysateLane 4 : HeLa cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-Apc6 antibody [EPR11168] - ab169536 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR11168
All lanes : Anti-Apc6 antibody [EPR11168] (ab169536) at 1/1000 dilutionLane 1 : HT-1080 cell lysateLane 2 : HepG2 cell lysateLane 3 : HeLa cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labeled goat anti-rabbit at 1/2000 dilution

Anti-Apc6 antibody [EPR16889] - ab181567 from Abcam

Prices $99.00
Sizes 10 µl
Host Rabbit
Clonality Monoclonal
Clone EPR16889
All lanes : Anti-Apc6 antibody [EPR16889] (ab181567) at 1/5000 dilutionLane 1 : L-929 (Mouse connective tissue fibroblast cells) whole cell lysates at 20 µgLane 2 : HeLa (Human epithelial cells from cervix adenocarcinoma) whole cell lysates at 20 µgLane 3 : HepG2 (Human liver hepatocellular carcinoma) whole cell lysates at 20 µgLane 4 : HT1080 (Human fibrosarcoma cells) whole cell lysates at 10 µgSecondaryGoat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/1000 dilution

Anti-APC6 / CDC16 Antibody - LS-C121186 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-APC6 / CDC16 Antibody (Internal) - LS-C145124 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-APC6 / CDC16 Antibody (aa87-136) - LS-C187227 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-APC6 / CDC16 Antibody (aa175-225) - LS-C286045 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-APC6 / CDC16 Antibody (aa570-620) - LS-C287989 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-APC6 / CDC16 Antibody (Glu206) - LS-C176862 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of Cdc16 (E206) pAb in extracts from NIH-3T3 cells.

Anti-APC6 / CDC16 Antibody (aa181-230) - LS-C119437 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from NIH-3T3 cells, using APC6 Antibody. The lane on the right is treated with the synthesized peptide.
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