| Gene Symbol | CCNH |
|---|---|
| Entrez Gene | 902 |
| Alt Symbol | CAK, CycH, p34, p37 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cyclin H |
| Other Description | CAK complex subunit|CDK-activating kinase complex subunit|MO15-associated protein|cyclin-H|cyclin-dependent kinase-activating kinase complex subunit |
| Swissprots | Q8TBL9 P51946 Q53X72 |
| Accessions | AAL74271 EAW95934 EAW95935 P51946 AB209342 BAD92579 AI761780 AK094534 AK291720 BAF84409 BC005280 AAH05280 BC016705 AAH16705 BC016823 AAH16823 BC022351 AAH22351 BF510957 BG718714 BP244381 BX537673 CB240639 CR407658 CAG28586 DA079651 DQ892550 ABM83476 DQ895761 ABM86687 U11791 AAA21361 U12685 AAA57006 XM_005248627 XP_005248684 XM_005248629 XP_005248686 XM_011543706 XP_011542008 NM_001199189 NP_001186118 NM_001239 NP_001230 |
| Function | Regulates CDK7, the catalytic subunit of the CDK- activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:7533895}. |
| Subcellular Location | Nucleus. |
| Top Pathways | Cell cycle, Nucleotide excision repair, Basal transcription factors |