Acsl4

Gene Symbol Acsl4
Entrez Gene 50790
Alt Symbol 9430020A05Rik, ACS4, AU018108, Facl4, Lacs4
Species Mouse
Gene Type protein-coding
Description acyl-CoA synthetase long-chain family member 4
Other Description LACS 4|fatty acid-Coenzyme A ligase, long chain 4|long-chain acyl-CoA synthetase 4|long-chain-fatty-acid--CoA ligase 4|mACS4
Swissprots Q5D071 Q9QUJ7 Q9R0H3 Q9JHT4
Accessions CBF65116 CBU89987 EDL14748 EDL14749 EDL14750 Q9QUJ7 AB033885 BAA85929 AB033886 BAA85930 AB033887 BAA85931 AJ243502 CAB95965 AK034650 AK054387 BAC35758 AK165950 AK181492 BB857663 BC016416 AAH16416 BC058663 AAH58663 XM_011247842 XP_011246144 XM_011247843 XP_011246145 NM_001033600 NP_001028772 NM_019477 NP_062350 NM_207625 NP_997508
Function Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates.
Subcellular Location Mitochondrion outer membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Peroxisome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.
Tissue Specificity Abundant in steroidogenic tissues, also found in the kidney, brain and liver.
Top Pathways Adipocytokine signaling pathway, PPAR signaling pathway, Peroxisome, Fatty acid biosynthesis, Fatty acid degradation