| Gene Symbol | DIAPH2 |
|---|---|
| Entrez Gene | 1730 |
| Alt Symbol | DIA, DIA2, DRF2, POF, POF2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | diaphanous-related formin 2 |
| Other Description | diaphanous homolog 2|diaphanous-related formin-2|diaphorase-2|protein diaphanous homolog 2 |
| Swissprots | Q9UJL2 Q8WX48 A6NG19 O60878 O60879 Q8WX06 |
| Accessions | CAJ42758 EAX02791 EAX02792 EAX02793 O60879 AK002029 BAG51003 AK291272 BAF83961 AW276516 BC117414 AAI17415 BC143838 AAI43839 BX363708 DB062196 U69179 Y15908 CAA75869 Y15909 CAA75870 NM_006729 NP_006720 NM_007309 NP_009293 |
| Function | Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton. {ECO:0000269|PubMed:12577064}. |
| Subcellular Location | Isoform 3: Cytoplasm, cytosol. Early endosome. Note=Isoform 3 is cytosolic but when coexpressed with RHOD, the 2 proteins colocalize to early endosomes. |
| Tissue Specificity | Expressed in testis, ovary, small intestine, prostate, lung, liver, kidney and leukocytes. |
| Top Pathways | Regulation of actin cytoskeleton |