| Gene Symbol | CAD |
|---|---|
| Entrez Gene | 790 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase |
| Other Description | CAD protein|CAD trifunctional protein|multifunctional protein CAD |
| Swissprots | P27708 Q6P0Q0 Q96CK3 D6W552 |
| Accessions | AAA51907 AAX93165 AAY24293 EAX00612 EAX00613 EAX00614 P27708 AB621827 BAK64162 AK226105 BC014178 AAH14178 BC065510 AAH65510 BG766243 BM927624 BQ447516 BU541191 BU558264 D78586 BAA11423 XM_005264555 XP_005264612 XM_005264556 XP_005264613 XM_005264557 XP_005264614 XM_005264558 XP_005264615 XM_006712101 XP_006712164 NM_001306079 NP_001293008 NM_004341 NP_004332 |
| Function | This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase). {ECO:0000269|PubMed:24332717}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:15890648}. Nucleus {ECO:0000269|PubMed:15890648}. Note=Cytosolic and unphosphorylated in resting cells, translocates to the nucleus in response to EGF stimulation, nuclear import promotes optimal cell growth. |
| Top Pathways | Alanine, aspartate and glutamate metabolism, Pyrimidine metabolism |