| Gene Symbol | FUT3 |
|---|---|
| Entrez Gene | 2525 |
| Alt Symbol | CD174, FT3B, FucT-III, LE, Les |
| Species | Human |
| Gene Type | protein-coding |
| Description | fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) |
| Other Description | Lewis FT|alpha-(1,3/1,4)-fucosyltransferase|blood group Lewis alpha-4-fucosyltransferase|fucosyltransferase III|galactoside 3(4)-L-fucosyltransferase |
| Swissprots | Q99449 P21217 Q99448 B5U7V0 B5U7U9 Q32NE7 |
| Accessions | AAW34365 BAA13941 BAA13942 BAA96390 CAQ56302 CAQ68512 CAQ68513 CAQ68514 CAQ81986 CAQ81987 CAR64692 CAR64693 EAW69135 P21217 AF131913 AAD33514 AK291852 BAF84541 AK313575 BAG36347 BC074836 AAH74836 BC074837 AAH74837 BC108675 AAI08676 BM671165 DA876997 DA930897 DB200655 U27326 AAC50185 U27327 AAC50186 U27328 AAC50187 X53578 CAA37641 XM_011527865 XP_011526167 XM_011527866 XP_011526168 XM_011527867 XP_011526169 NM_000149 NP_000140 NM_001097639 NP_001091108 NM_001097640 NP_001091109 NM_001097641 NP_001091110 |
| Function | May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination; Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme. Also acts on the corresponding 1,4-galactosyl derivative, forming 1,3-L-fucosyl links. |
| Subcellular Location | Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi. |
| Tissue Specificity | Highly expressed in stomach, colon, small intestine, lung and kidney and to a lesser extent in salivary gland, bladder, uterus and liver. |
| Top Pathways | Glycosphingolipid biosynthesis - lacto and neolacto series |