| Gene Symbol | C4BPA |
|---|---|
| Entrez Gene | 722 |
| Alt Symbol | C4BP, PRP |
| Species | Human |
| Gene Type | protein-coding |
| Description | complement component 4 binding protein, alpha |
| Other Description | C4b-binding protein alpha chain|proline-rich protein |
| Swissprots | Q5VVQ8 P04003 |
| Accessions | AAA36506 CAA27839 CAB51244 EAW93500 EAW93501 EAW93502 EAW93503 P04003 AK303793 BAG64750 AK303798 BAG64753 AK313164 BAG35982 BC022312 AAH22312 BQ019292 DQ892021 ABM82947 DQ895213 ABM86139 M31452 AAA36507 X02865 CAA26617 X07853 CAA30701 XM_005273251 XP_005273308 XM_005273252 XP_005273309 NM_000715 NP_000706 |
| Function | Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component. |
| Subcellular Location | Secreted. |
| Tissue Specificity | Chylomicrons in the plasma. |
| Top Pathways | Complement and coagulation cascades, Pertussis |