| Gene Symbol | OLAH |
|---|---|
| Entrez Gene | 55301 |
| Alt Symbol | AURA1, SAST, THEDC1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | oleoyl-ACP hydrolase |
| Other Description | S-acyl fatty acid synthase thioesterase, medium chain|augmented in rheumatoid arthritis 1|thioesterase II|thioesterase domain containing 1|thioesterase domain-containing protein 1 |
| Swissprots | Q9NUW1 Q5VUB6 Q9NV23 |
| Accessions | CAE89822 EAW86244 EAW86245 Q9NV23 AK001844 BAA91937 AK001968 BAA92007 BC050372 AAH50372 BG281536 BG722790 BI830605 BR000403 FAA00320 HQ448637 ADQ33115 XM_006717456 XP_006717519 NM_001039702 NP_001034791 NM_018324 NP_060794 |
| Function | In fatty acid biosynthesis chain termination and release of the free fatty acid product is achieved by hydrolysis of the thio ester by a thioesterase I, a component of the fatty acid synthetase complex. The chain length of the released fatty acid is usually C16. However, in the mammary glands of non-ruminant mammals, and in the uropygial gland of certain waterfowl there exists a second thioesterase which releases medium-chain length fatty acids (C8 to C2) (By similarity). {ECO:0000250}. |
| Tissue Specificity | Isoform 2 is up-regulated in bone marrow- derived mononuclear cells of rheumatoid arthritis patients. {ECO:0000269|PubMed:17082220}. |
| Top Pathways | Fatty acid biosynthesis |