RPRD1B

Gene Symbol	RPRD1B
Entrez Gene	58490
Alt Symbol	C20orf77, CREPT, NET60, dJ1057B20.2
Species	Human
Gene Type	protein-coding
Description	regulation of nuclear pre-mRNA domain containing 1B
Other Description	cell cycle-related and expression-elevated protein in tumor|cell-cycle related and expression-elevated protein in tumor|regulation of nuclear pre-mRNA domain-containing protein 1B
Swissprots	Q1WDE7 Q9NQG5 Q6PKF4
Accessions	EAW76045 EAW76046 Q9NQG5 AK092567 AK126484 AK312468 BAG35375 AL080224 AL117521 CAH10720 BC001696 AAH01696 BC020939 BC033629 AAH33629 BP359144 DQ372938 ABD34791 XM_005260477 XP_005260534 XM_005260480 XP_005260537 XM_011528954 XP_011527256 XR_936597 NM_021215 NP_067038
Function	Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation. {ECO:0000269|PubMed:22231121, ECO:0000269|PubMed:22264791}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:22264791}.
Tissue Specificity	Preferentially expressed in a range of tumor tissues including colon, lung, liver, breast, prostate, stomach, uterine endometrium and cervical cancers with higher levels in tumors than in adjacent non-tumor tissue (at protein level). {ECO:0000269|PubMed:22264791}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human C20orf77 full length protein - ab163678 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human C20orf77 full length protein - ab202606 from Abcam Category Protein Prices $429.00 Sizes 100 µg Source E. coli Species Human

RPRD1B Antibody Blocking Peptide - LS-E21007 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RPRD1B Antibody Blocking Peptide - LS-E10390 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RPRD1B Recombinant Protein - H00058490-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

RPR1B-Antibody-C-term-Blocking-Peptide - BP9920b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human RPRD1B protein (His Tag) - orb139600 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source Human Cells Species Human

RPRD1B Blocking Peptide - 33R-4494 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RPRD1B protein (His tag) - 80R-4180 from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg Source E.coli

RPRD1B (1-326, His-tag) - AR51868PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

RPRD1B (1-326, His-tag) - AR51868PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

RPRD1B - H00058490-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RPRD1B - H00058490-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RPRD1B fusion protein - Ag21578 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET30a Species Human

Recombinant Human RPRD1B, His tagged - RPRD1B-374H from Creative Biomart Category Protein Source Human Cells Species Human

Human RPRD1B Protein (His Tag) - 14027-H07H-100 from Sino Biological Category Protein Prices $138.00, $348.00 Sizes 20 µg, 100 µg Source Human Cells Species Human

Recombinant Human Regulation of nuclear pre-mRNA domain-containing protein 1B(RP - CSB-YP878854HU CSB-EP878854HU CSB-BP878854HU CSB-MP878854HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

RPRD1B, 1-326aa, Human, His tag, E.coli - ATGP3048 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 20 µg, 100 µg, 500 µg Species Human

RPRD1B - TP307481 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

RPRD1B Peptide, Human - M34GP13561H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Human RPRD1B Protein - NBP2-52051 from Novus Biologicals Category Protein Prices $259.00, $759.00 Sizes 100 µg, 500 µg Source E.coli Species Human

RPRD1B - PAT-82983-2 from Nordic BioSite Category Protein Species Human

RPRD1B - PAT-82983-1 from Nordic BioSite Category Protein Species Human

Regulation Of Nuclear Pre-MRNA Domain Containing 1B, Human Recombinant - 228-22312-1 from RayBiotech Category Protein Species Human

RPRD1B Recombinant Protein Antigen - NBP2-55788PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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