| Gene Symbol | RPRD1B |
|---|---|
| Entrez Gene | 58490 |
| Alt Symbol | C20orf77, CREPT, NET60, dJ1057B20.2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | regulation of nuclear pre-mRNA domain containing 1B |
| Other Description | cell cycle-related and expression-elevated protein in tumor|cell-cycle related and expression-elevated protein in tumor|regulation of nuclear pre-mRNA domain-containing protein 1B |
| Swissprots | Q1WDE7 Q9NQG5 Q6PKF4 |
| Accessions | EAW76045 EAW76046 Q9NQG5 AK092567 AK126484 AK312468 BAG35375 AL080224 AL117521 CAH10720 BC001696 AAH01696 BC020939 BC033629 AAH33629 BP359144 DQ372938 ABD34791 XM_005260477 XP_005260534 XM_005260480 XP_005260537 XM_011528954 XP_011527256 XR_936597 NM_021215 NP_067038 |
| Function | Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation. {ECO:0000269|PubMed:22231121, ECO:0000269|PubMed:22264791}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:22264791}. |
| Tissue Specificity | Preferentially expressed in a range of tumor tissues including colon, lung, liver, breast, prostate, stomach, uterine endometrium and cervical cancers with higher levels in tumors than in adjacent non-tumor tissue (at protein level). {ECO:0000269|PubMed:22264791}. |