RNF8

Gene Symbol	RNF8
Entrez Gene	9025
Alt Symbol	hRNF8
Species	Human
Gene Type	protein-coding
Description	ring finger protein 8, E3 ubiquitin protein ligase
Other Description	C3HC4-type zinc finger protein|E3 ubiquitin-protein ligase RNF8|UBC13/UEV-interacting ring finger protein|ring finger protein (C3HC4 type) 8
Swissprots	A8MYC0 A6NN24 O76064 Q5NKW5 Q53H16 B4DPG0
Accessions	BAA33557 EAX03943 EAX03944 EAX03945 O76064 AB014546 BAA31621 AF334675 AAQ14887 AK022075 AK222765 BAD96485 AK298319 BAG60572 AK308840 AL711279 BC007517 AAH07517 BE327572 BF110581 BG029939 BM979512 BT007446 AAP36114 CA418096 DA064222 DQ890737 ABM81663 DQ893909 ABM84835 XM_006715241 XP_006715304 XM_006715242 XP_006715305 XR_427852 XR_427853 XR_427854 XR_427855 XR_427856 XR_427857 XR_926336 NM_003958 NP_003949 NM_183078 NP_898901 NR_046399
Function	E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'- linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20/C1orf86 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-de
Subcellular Location	Nucleus. Midbody. Chromosome, telomere {ECO:0000250}. Note=Recruited at uncapped telomeres (By similarity). Following DNA double-strand breaks, recruited to the sites of damage. During prophase, concomitant with nuclear envelope breakdown, localizes throughout the cell, with a dotted pattern. In telophase, again in the nucleus and also with a discrete dotted pattern in the cytoplasm. In late telophase and during cytokinesis, localizes in the midbody of the tubulin bridge joining the daughter cells. Does not seem to be associated with condensed chromosomes at any time during the cell cycle. {ECO:0000250}.
Tissue Specificity	Ubiquitous. In fetal tissues, highest expression in brain, thymus and liver. In adult tissues, highest levels in brain and testis, lowest levels in peripheral blood cells. {ECO:0000269|PubMed:16215985, ECO:0000269|PubMed:9852682}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RNF8 full length protein - ab131927 from Abcam Category Protein Source Wheat germ Species Human

Human RNF8 peptide - ab24680 from Abcam Category Peptide

Human RNF8 peptide - ab23278 from Abcam Category Peptide Species Human

RNF8 Antibody Blocking Peptide - LS-E2420 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RNF8 Antibody Blocking Peptide - LS-E14573 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RNF8 Antibody Blocking Peptide - LS-E25497 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RNF8 Antibody Blocking Peptide - LS-E30931 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human RNF8 Protein - H00009025-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RNF8 Blocking Peptide - NBP1-77166PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

RNF8-Antibody-C-term-Blocking-peptide - BP13431b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RNF8 blocking peptide - GTX15850-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

RNF8 Blocking Peptide - 33R-5906 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RNF8 Peptide - AC21-0326-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

RNF8 - H00009025-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RNF8 - H00009025-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RNF8 control peptide - AP26208CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

RNF8 Peptide - 5763P from ProSci Category Peptide Species Human

RNF8 Peptide - 46-313P from ProSci Category Peptide Species Human

RNF8 fusion protein - ag4480 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

RNF8 fusion protein - Ag5292 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human E3 ubiquitin-protein ligase RNF8(RNF8) - CSB-YP019898HU CSB-EP019898HU CSB-BP019898HU CSB-MP019898HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

RNF8, Peptide - MBS425412 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human

RNF8 Peptide, Human - M34GP13445H from Creative Peptides Category Peptide Source Synthetic. Species Human

RNF8 Recombinant Protein Antigen - NBP2-48974PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

E3 ubiquitin-protein ligase RNF8 (RNF8), Recombinant Protein - MBS1136887 from MyBioSource Category Protein Prices $1,270.00, $1,270.00, $1,490.00, $1,490.00, $2,075.00, $2,075.00, $2,540.00, $2,540.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Search more