| Gene Symbol | crb |
|---|---|
| Entrez Gene | 42896 |
| Alt Symbol | 0509/20, 1384/04, CG6383, CRB, CT19912, Crb, Crbs, Crumbs, Dmel\CG6383, crumb, far, l(3)07207, l(3)S050920, l(3)S058104, l(3)j1B5 |
| Species | Drosophila |
| Gene Type | protein-coding |
| Description | crumbs |
| Other Description | CG6383-PA|CG6383-PB|CG6383-PC|CG6383-PD|crb-PA|crb-PB|crb-PC|crb-PD|fat rhabdomere|fat rhabdomeres|lethal (3) 07207|merlin |
| Swissprots | Q9VC97 Q8MSX5 Q0KI19 P10040 |
| Accessions | AAF56276 ABI31202 AFH06602 AGB96289 P10040 NM_001043286 NP_001036751 NM_001260355 NP_001247284 NM_001275980 NP_001262909 NM_079756 NP_524480 |
| Function | Plays a central role in cell polarity establishment. Participates in the assembly, positioning and maintenance of adherens junctions via its interaction with the SAC complex. Controls the coalescence of the spots of zonula adherens (ZA) into a adhesive ring around the cells. It may act as a signal. Involved in morphogenesis of the photoreceptor rhabdomere, for positioning and growth of rhabdomere and AJ during the crucial period of photoreceptor extension along the proximodistal axis of the retina. {ECO:0000269|PubMed:2344615}. |
| Subcellular Location | Apical cell membrane {ECO:0000269|PubMed:11076972, ECO:0000269|PubMed:2344615}; Single- pass type I membrane protein {ECO:0000269|PubMed:11076972, ECO:0000269|PubMed:2344615}. Note=Specifically localized to the apical membrane. |
| Top Pathways | Hippo signaling pathway - fly |