| Gene Symbol |
SHB
|
| Entrez Gene |
6461
|
| Alt Symbol |
bA3J10.2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Src homology 2 domain containing adaptor protein B
|
| Other Description |
SH2 domain-containing adapter protein B|SHB (Src homology 2 domain containing) adaptor protein B|SHB adaptor protein (a Src homology 2 protein)
|
| Swissprots |
Q15464 Q504U5 B9EGM0 D3DRQ5 Q5VUM8
|
| Accessions |
EAW58254 EAW58255 Q15464 AK055947 AK096227 BC029953 BC136581 AAI36582 BC136582 AAI36583 X75342 CAA53091 NM_003028 NP_003019
|
| Function |
Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic- FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells. {ECO:0000269|PubMed:10828022, ECO:0000269|PubMed:10837138, ECO:0000269|PubMed:12084069, ECO:0000269|PubMed:12464388, ECO:0000269|PubMed:12520086, ECO:0000269|PubMed:15026417, ECO:0000269|PubMed:15919073, ECO:0000269|PubMed:8806685, ECO:0000269|PubMed:9484780, ECO:0000269|PubMed:9751119}.
|
| Subcellular Location |
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associates with membrane lipid rafts upon TCR stimulation.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:9484780}.
|