| Gene Symbol | chcA |
|---|---|
| Entrez Gene | 8620910 |
| Alt Symbol | DDBDRAFT_0169102, DDBDRAFT_0185029, DDB_0169102, DDB_0185029 |
| Species | Dictyostelium discoideum |
| Gene Type | protein-coding |
| Description | clathrin heavy chain |
| Other Description | - |
| Swissprots | Q54ZZ9 P25870 |
| Accessions | EAL68796 Q54ZZ9 XM_637625 XP_642717 |
| Function | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. {ECO:0000269|PubMed:10588667, ECO:0000269|PubMed:10591622, ECO:0000269|PubMed:11223952, ECO:0000269|PubMed:1522112, ECO:0000269|PubMed:8034739, ECO:0000269|PubMed:9053320, ECO:0000269|PubMed:9238018}. |
| Subcellular Location | Cytoplasmic vesicle membrane {ECO:0000269|PubMed:10848635}; Peripheral membrane protein {ECO:0000269|PubMed:10848635}; Cytoplasmic side {ECO:0000269|PubMed:10848635}. Membrane, coated pit {ECO:0000269|PubMed:10848635}; Peripheral membrane protein {ECO:0000269|PubMed:10848635}; Cytoplasmic side {ECO:0000269|PubMed:10848635}. Note=Cytoplasmic face of coated pits and vesicles. Localized to punctae scattered within the cytoplasm, along the plasma membrane and concentrated in the perinuclear region. Localizes to the posterior plasma membrane in cells which retract their tails when moving forward or changing direction. Recruited to the plasma membrane under the tight cap of cross-linked receptors prior to internalisation of the capped ligand. Does not localize to the plasma membrane during phagocytosis. |
| Top Pathways | Endocytosis |