| Gene Symbol | TAF1 |
|---|---|
| Entrez Gene | 6872 |
| Alt Symbol | BA2R, CCG1, CCGS, DYT3, DYT3/TAF1, KAT4, N-TAF1, NSCL2, OF, P250, TAF(II)250, TAF2A, TAFII-250, TAFII250, XDP |
| Species | Human |
| Gene Type | protein-coding |
| Description | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa |
| Other Description | TBP-associated factor 250 kDa|cell cycle gene 1 protein|cell cycle, G1 phase defect|complementation of cell cycle block, G1-to-S|transcription factor TFIID p250 polypeptide|transcription initiation factor TFIID subunit 1 |
| Swissprots | Q70T03 Q70T00 Q59FZ3 Q6IUZ1 A5CVC8 A5CVC9 P21675 Q70Q86 Q70T01 A5CVD0 Q70T02 A5CVD1 B1Q2X3 Q70Q87 |
| Accessions | AAT38105 EAX05291 EAX05292 EAX05293 EAX05294 EAX05295 P21675 AB209316 BAD92553 AB300418 BAG15901 AJ549245 CAD70488 AJ549246 CAD70489 AJ549247 CAD70490 AJ549248 CAD70491 AJ549249 CAD70492 AJ549250 CAD70493 AJ555148 CAD87527 AJ555149 CAD87528 AK310201 AM711892 CAM98555 AM711893 CAM98556 AM711894 CAM98557 AM711895 CAM98558 AW937788 BC172427 AAI72427 BP284702 BQ027170 D90359 BAA14374 M73444 R66536 X07024 CAA30073 XM_005262295 XP_005262352 XM_005262296 XP_005262353 XM_005262297 XP_005262354 XM_005262300 XP_005262357 XM_006724682 XP_006724745 XM_011531016 XP_011529318 XR_938407 NM_001286074 NP_001273003 NM_004606 NP_004597 NM_138923 NP_620278 NR_104387 NR_104388 NR_104389 NR_104390 NR_104391 NR_104392 NR_104393 NR_104394 NR_104395 NR_104396 |
| Function | Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA- binding activity. Essential for progression of the G1 phase of the cell cycle. Exhibits histone acetyltransferase activity towards histones H3 and H4. {ECO:0000269|PubMed:11278496, ECO:0000269|PubMed:15053879, ECO:0000269|PubMed:2038334, ECO:0000269|PubMed:8450888, ECO:0000269|PubMed:8625415, ECO:0000269|PubMed:9660973, ECO:0000269|PubMed:9858607}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:2038334}. |
| Top Pathways | Basal transcription factors |