| Gene Symbol | ECs2715 |
|---|---|
| Entrez Gene | 912330 |
| Alt Symbol | - |
| Species | Escherichia coli |
| Gene Type | protein-coding |
| Description | EspF-like protein |
| Other Description | - |
| Swissprots | Q8X2D5 P0DJ88 P0DJ89 |
| Accessions | BAB36138 NP_310742 |
| Function | Required for efficient pedestal formation in host epithelial cells during infection. Acts as an intermediate between Tir (via host BAIAP2) and host WASL/N-WASP. Directly binds and activates WASL/N-WASP, which stimulates actin polymerization and leads to the formation of actin pedestals at the sites of bacterial adhesion. {ECO:0000269|PubMed:18650809, ECO:0000269|PubMed:22921828}. |
| Subcellular Location | Secreted {ECO:0000250}. Host cytoplasm {ECO:0000250}. Note=Secreted via the type III secretion system (TTSS). In host cells, localizes to the tip of the actin pedestal (By similarity). {ECO:0000250}. |
| Top Pathways | Pathogenic Escherichia coli infection |