SH3PXD2A

Gene Symbol SH3PXD2A
Entrez Gene 9644
Alt Symbol FISH, SH3MD1, TKS5
Species Human
Gene Type protein-coding
Description SH3 and PX domains 2A
Other Description SH3 and PX domain-containing protein 2A|SH3 multiple domains 1|adapter protein TKS5|adaptor protein TKS5|five SH3 domain-containing protein|tyrosine kinase substrate with five SH3 domains
Swissprots Q5TCZ1 D3DR98 Q5TDQ8 Q5TCZ2 O43302
Accessions EAW49622 EAW49623 EAW49624 EAW49625 Q5TCZ1 AB007878 BAA24848 AK025783 AK056469 BAG51723 AK096575 AK123570 AK294454 BAH11772 AK294736 BAH11864 AK295314 BAH12031 AK295660 BAH12146 AK302015 BAH13608 AK304828 BAH14262 AK315983 BAH14354 AL833070 CAD89969 BC146309 AAI46310 BC156572 AAI56573 BX647371 CN307901 XM_005270294 XP_005270351 XM_005270295 XP_005270352 XM_005270297 XP_005270354 XM_005270298 XP_005270355 XM_006718079 XP_006718142 XM_006718080 XP_006718143 XM_011540385 XP_011538687 XM_011540386 XP_011538688 XM_011540387 XP_011538689 NM_014631 NP_055446
Function Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497}.
Subcellular Location Cytoplasm. Cell projection, podosome. Note=Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells.
Tissue Specificity Found in several cancer cell lines, particularly invasive breast carcinomas and melanomas. {ECO:0000269|PubMed:15710328}.

fish CRISPR/Cas9 KO Plasmid (h) - sc-401277 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

fish HDR Plasmid (h) - sc-401277-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

fish Double Nickase Plasmid (h) - sc-401277-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

fish Double Nickase Plasmid (h2) - sc-401277-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

fish CRISPR Activation Plasmid (h) - sc-401277-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

fish CRISPR Activation Plasmid (h2) - sc-401277-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

fish Lentiviral Activation Particles (h) - sc-401277-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

fish Lentiviral Activation Particles (h2) - sc-401277-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

fish siRNA (h) - sc-35376 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

fish shRNA Plasmid (h) - sc-35376-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

fish shRNA (h) Lentiviral Particles - sc-35376-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU133491 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19276 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19276 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SH3PXD2A siRNA (Human) - CRH6421 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SH3PXD2A - MBS8230616 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

fish CRISPR/Cas9 KO Plasmid (h2) - sc-401277-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

fish HDR Plasmid (h2) - sc-401277-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human SH3PXD2A (NM_014631.2) - SHH406812 from Creative biogene

Category siRNA
Species Reactivities Human

SH3PXD2A shRNA Plasmid (Human) - CHH6421 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SH3PXD2A miRNA 3'UTR clone - MiUTR1H-09367 from Creative biogene

Species Reactivities Human
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