| Name | Pan-Cadherin Antibody |
|---|---|
| Supplier | ABBIOTEC |
| Catalog | 251786 |
| Prices | $292.00 |
| Sizes | 100 µg |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Clone | PC-79 |
| Applications | ELISA IHC WB |
| Species Reactivities | Chicken |
| Antigen | KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of chicken pan-cadherin. |
| Purity/Format | Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 2% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography. |
| Description | Cadherins are calcium dependent cell adhesion proteins. Cadherins preferentially interact with themselves in a homophilic manner in connecting cells. Cadherins contribute to the sorting of heterogeneous cell types. N-cadherin functions during gastrulation and is required for establishment of left-right asymmetry. N-Cadherin is commonly found in cancer cells and provides a mechanism for transendothelial migration. When a cancer cell adheres to the endothelial cells of a blood vessel it up-regulates the src kinase pathway which phosphorylates beta-catenins attached to both N-cadherin and E-cadherins. |
| Gene | CDH2 |
| Supplier Page | Shop |